Detalhe da pesquisa
1.
Discovery of a structural class of antibiotics with explainable deep learning.
Nature
; 626(7997): 177-185, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123686
2.
GSK3α, not GSK3ß, drives hippocampal NMDAR-dependent LTD via tau-mediated spine anchoring.
EMBO J
; 40(2): e105513, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33197065
3.
Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants.
Proc Natl Acad Sci U S A
; 117(45): 28201-28211, 2020 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33106425
4.
MISCAST: MIssense variant to protein StruCture Analysis web SuiTe.
Nucleic Acids Res
; 48(W1): W132-W139, 2020 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32402084
5.
Multimodal small-molecule screening for human prion protein binders.
J Biol Chem
; 295(39): 13516-13531, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32723867
6.
Roles of glycogen synthase kinase 3 alpha and calcineurin in regulating the ability of sperm to fertilize eggs.
FASEB J
; 34(1): 1247-1269, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31914663
7.
Multigram Preparation of BRD4780 Enantiomers and Assignment of Absolute Stereochemistry.
J Org Chem
; 86(5): 4281-4289, 2021 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33618515
8.
Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.
Biochemistry
; 57(26): 3916-3924, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29775292
9.
Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.
J Biol Chem
; 292(43): 17598-17608, 2017 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28860191
10.
Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts.
J Pharmacol Exp Ther
; 361(1): 140-150, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28174211
11.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Bioorg Med Chem
; 24(18): 4008-4015, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377864
12.
Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.
Proc Natl Acad Sci U S A
; 110(24): 9806-11, 2013 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23720316
13.
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Angew Chem Int Ed Engl
; 55(33): 9601-5, 2016 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27355874
14.
Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.
J Neurosci
; 34(43): 14328-37, 2014 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25339746
15.
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.
Proc Natl Acad Sci U S A
; 109(14): 5364-9, 2012 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22434908
16.
Studies toward the total synthesis of dihydrolycolucine. Preparation of AB and CEF ring fragments.
J Org Chem
; 79(12): 5740-5, 2014 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24841361
17.
Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.
J Org Chem
; 77(17): 7187-211, 2012 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22853001
18.
Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators.
ACS Pharmacol Transl Sci
; 5(3): 156-168, 2022 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35311021
19.
Virtual screening for small-molecule pathway regulators by image-profile matching.
Cell Syst
; 13(9): 724-736.e9, 2022 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36057257
20.
The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes.
SLAS Discov
; 26(7): 855-861, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34130532